Both my Santa Cruz Nomad and my On One Scandal mountain bikes are running tubeless setups now. So far so good. Both are working well and I like the feel of the tires at lower pressures without fear of pinch flats. Tubeless tires are supposed to roll faster and provide better “feel” than the same time with a tube inside. I can’t confirm or deny that aspect. They certainly don’t roll any slower!
Installation on both bikes was simple and there have been no hassles keeping them rolling along. For my mountain bikes I can’t see any reason to go back to tubes. I want to run tubeless on my Pugsley as it would save a lot of weight per wheel given the heavy tubes it uses. I’m even thinking of converting Sharon’s commuter bike to tubeless when the tires wear out next.